�Eli Lilly and Co (NYSE:
LLY) and Boehringer Ingelheim receive announced that the European Commission
has approved the use of Cymbalta(R) (duloxetine) for the treatment of
Generalised Anxiety Disorder (GAD). This approval -- the fourth for
duloxetine in Europe -- was issued on 28 July following an initial positive
opinion issued by the European Medicines Agency's (EMEA) Committee for
Medicinal Products for Human Use (CHMP) on 26 June 2008.
The approval is based upon the results of phoebe clinical studies of GAD
-- four-spot double-blind short-term (acute) placebo-controlled studies and a
placebo-controlled relapse prevention study -- involving more than than 2,000
non-depressed adults with GAD. In each of the iV acute placebo-controlled
studies safety and efficaciousness were assessed. Duloxetine significantly
improved core anxiety symptoms (as deliberate by the Hamilton Anxiety Scale)
compared with placebo (p less than or equal to 0.001, p=0.02, p=0.007, p
less than or equal to 0.001 respectively)(1,2,3,4) and patients
demonstrated improvement in role operation, including ability to do
everyday activities in work, home and in social situations.(5,6) In
addition, duloxetine significantly reduced the likeliness of get worse in
those patients wHO initially responded to duloxetine and were maintained on
treatment for six months compared with those switched to placebo.(7) The
most vulgar side personal effects in these studies included nausea, fatigue, dry
mouth, drowsiness, irregularity, insomnia, reduced appetite,
hyperidrosis (excessive perspiration), decreased libido, vomiting,
ejaculation delay and erectile disfunction.
Although global prevalence is not presently known, more than club
million Europeans(8,9) and six million the great unwashed in Central and South America
ar estimated to suffer from GAD(10), which is characterised by inordinate
anxiety and worry most a number of events and activities (such as
performance at work or school) over a free burning period of at least six
months.(11)
This regulatory favourable reception paves the way for launches in Europe and
applies to all 27 countries of the European Union, as well as Norway,
Iceland, and Liechtenstein.
Cymbalta(R), a member of a class of drugs commonly referred to as
serotonin and noradrenaline reuptake inhibitors,(12) is already approved by
the EMEA to process major depressive disorder and diabetic peripheral
neuropathic painful sensation. Duloxetine gained marketing authorisation for the
treatment of GAD in Mexico in 2006 and in the United States in 2007.
About Generalised Anxiety Disorder
Approximately nine billion Europeans(8,9) and six million people in
Central and South America are estimated to hurt from GAD.(10) Quality of
life is affected, as symptoms of GAD tin include overdone worry or
chronic anxiousness, irritability and poor concentration. Ability to work is
often compromised with the manifestation of physical symptoms such as
muscle tension, fatigue, sleep disturbance and nausea.(11) The sickness
tends to be continuing with periods of exacerbation and remitment. Patients
report that episodes of generalised anxiety disorder are often brought on,
or worsened, by nerve-racking life events.(13)
About Duloxetine
While duloxetine's mechanism of activity in world is not fully known, it
is believed to affect both serotonin- and
ntinence is marketed by Lilly under
the steel name Yentreve.(R)
References
(1) Koponen, H., et al. Efficacy of Duloxetine for the Treatment of
Generalized Anxiety Disorder: Implications for Primary Care Physicians.
Prim Care Companion J Clin Psychiatry 2007: 9(2):100-107
(2) Rynn M., et al. Efficacy and Safety of Duloxetine in the Treatment of
Generalized Anxiety Disorder: A Flexible-Dose, Progressive-Titration,
Placebo-Controlled Trial. Depression and Anxiety 2007: 25(3): 182-189.
(3) Hartford, J., et al. Duloxetine as an SNRI Treatment for Generalized
Anxiety Disorder: Results from a Placebo- and Active-Controlled Trial. Int
Clin Psychopharmacol 2007: 22(3):167-74.
(4) Nicolini H, et al. Improvement of psychic and somatic symptoms in
adult patients with generalized anxiety disorder: Examination from a
duloxetine, venlafaxine extended-release, and placebo-controlled study. In
Press at Psychological Medicine.
(5) Endicott, J., et al. Duloxetine Treatment for Role Functioning
Improvement in Generalized Anxiety Disorder: Three Independent Studies. The
Journal of Clinical Psychiatry 2007: 68(4):518-24
(6) Allgulander, C., et al. Pharmacotherapy of Generalized Anxiety
Disorder: Results of Duloxetine Treatment from a Pooled Analysis of 3
Clinical Trials. Current Medical Research and Opinion 2007: 23(6):
1245-1252
(7) Davidson JRT, et al. Duloxetine intervention for get worse prevention in
adults with generalized anxiety disorder: A 26-week randomised placebo-
controlled study. Poster presented at the American College of
Neuropsychopharmacology annual conference 2007. Boca Raton, Florida
(8) Lieb, R, et al. The epidemiology of generalized anxiety upset in
Europe. European Neuropsychopharmacology 2005 Aug;15(4):445-52.
(9) National Institute of Economic and Social Research. Summarized from
the National Institute Economic Review,194, 28 October 2005.
(10) Calculated extrapolations of prevalence rates against the
populations of a particular country or region, based upon prevalence of
generalized anxiety disorder in the US, UK, Canada or Australia. Available
at:
hTTP://www.cureresearch.
Thursday, 4 September 2008
Monday, 25 August 2008
Download Omni Trio mp3
 Artist: Omni Trio: mp3 download Genre(s): Drum & Bass Jungle Discography:  Thru The Vibe Remixes Year: 2003 Tracks: 2  Omni Trio Year: 2003 Tracks: 2  Even Angels Cast Shadows Year: 2001 Tracks: 5  Old Scool D'n'B Year: 2000 Tracks: 7  Soul Promenade (Promo) Year: 1994 Tracks: 2 Actually the single force of unmatched Rob Haigh, Omni Trio's gay steel of intricate, orchestrated drum'n'bass has been ontogenesis in herald since the approach of "ambient" or "intelligent" jungle in the mid-'90s brought identify calling such as L.T.J Bukem, Spring Heel Jack, and TPower to the stem. Into his 30s, Haigh already had a tenner on to the highest degree of those name calling, a fact communicated in the frequently more eclectic influence behindhand his tunes -- from Carl Craig and Mantronix to Miles Davis and Can. An acolyte of London's mid-'80s experimental industrial/avant-garde scene, Haigh's first Omni Trio releases -- a series of 12-inches issued in classifiable, color-coded sleeves -- started to look in the early '90s. Following on the heels of former hard-core and darkside techno, Haigh's tunes were among the first base composed remote of jungle's immediate dancefloor loop, and were other examples of the music's voltage to draw on a all-embracing range of sources (ambient, sign of the zodiac, jazz, soul) for influence. His number one full-length album, Volume 1: The Deepest Cut, was released on Moving Shadow in 1995 and combined many of those early 12-inch tracks -- "Mystic Stepper," "Apostate Snares" -- with some stunning production and remix work on by Foul Play (on "Snares"), among others. His proper debut, Obsessed Science, was released by Moving Shadow in 1996; Skeleton in the closet Keys followed in 1997. In addition to his progressively successful career as a recording creative person and remixer, Haigh also owns and operates a record shop in Hertford. |
Role Of Obesity In Preeclampsia Studied At University Of Pittsburgh
Thursday, 7 August 2008
Soak
Artist: Soak
Genre(s):
Trance
Other
Discography:
Miraflores
Year: 2007
Tracks: 4
Soak
Year: 1997
Tracks: 13
Friday, 27 June 2008
Monday, 23 June 2008
Led Zeppelin DVD Of O2 Arena Show Coming?
Led Zeppelin could release a DVD of their reunion show at London's O2 Arena, that took place in December last year.
Two members of the band - guitarist Jimmy Page and bassist John Paul Jones - have not ruled out the DVD. When asked by BBC 6Music if fans can expect the release, Page said: "I hope so one day, yeah."
Although Jones did admit that "there is no hurry" to release the DVD, before adding: "It was a special occasion you know and we really wanted that just to be it really."
See Also
Monday, 16 June 2008
Candie Payne
Artist: Candie Payne
Genre(s):
Indie
Discography:
I Wish I Could Have Loved You More
Year: 2007
Tracks: 11
A singer/songwriter with a bent toward '60s influenced pop with indie Candie Payne was natural in Liverpool in 1983. However, she fatigued very much of her youth in Jackson Heights, Queens, NY, where she moved with her parents until reversive to England at eld ten. The sis of musician brothers Howie Payne รข€“ erstwhile of the Stands -- and drummer Sean Payne of the Zutons, Payne first-class honours degree played out time perusing art in college ahead falling out to pursue music. Influenced early on by such iconic jazz vocalists as Billie Holiday and Ella Fitzgerald, Payne likewise listened to heavily to a wide change of pop and rock music that she in the end brought to assume on her have songs. After working with several local Liverpool bands, Payne was introduced to producer Simon Dine and the pair began writing together. Evincing a '60s girl mathematical group and Motown-influenced vibe, Payne's debut album, I Wish I Could Have Loved You More, featured the Mark Ronson-produced single "Unitary More Chance" and was released on Sony in 2007.
Tomas Walker
Wednesday, 4 June 2008
J-Kwon
Artist: J-Kwon
Genre(s):
Other
Discography:
Hood Hop
Year: 2006
Tracks: 18
Tipsy
Year: 2004
Tracks: 4
J-Kwon's path to celebrity included mooning Arista drumhead L.A. Reid and mocking producer Jermaine Dupri. These events helped realise the MC a narrow with the latter's So So Def, a subsidiary company of the former's employer. However, his animation was far more than roiled earlier that; kicked stunned his mother's mansion at the eld of 12, he took to the street, dealt break cocain, and had his chat broken after defeating a fellow MC in struggle. His label deal helped bend that about. Before turning 18, his debut single, "Tipsy," had reached the Top Ten of precisely about every singles chart. Overseen by Dupri and produced near in full by the Track Boyz, J-Kwon's full-length debut -- Hoodlum Hop, released in March of 2004 -- appeared precisely as the hit was decent unavoidable.
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