Cymbalta Receives European Approval For The Treatment Of Generalised Anxiety Disorder

�Eli Lilly and Co (NYSE:
LLY) and Boehringer Ingelheim receive announced that the European Commission
has approved the use of Cymbalta(R) (duloxetine) for the treatment of
Generalised Anxiety Disorder (GAD). This approval -- the fourth for
duloxetine in Europe -- was issued on 28 July following an initial positive
opinion issued by the European Medicines Agency's (EMEA) Committee for
Medicinal Products for Human Use (CHMP) on 26 June 2008.



The approval is based upon the results of phoebe clinical studies of GAD
-- four-spot double-blind short-term (acute) placebo-controlled studies and a
placebo-controlled relapse prevention study -- involving more than than 2,000
non-depressed adults with GAD. In each of the iV acute placebo-controlled
studies safety and efficaciousness were assessed. Duloxetine significantly
improved core anxiety symptoms (as deliberate by the Hamilton Anxiety Scale)
compared with placebo (p less than or equal to 0.001, p=0.02, p=0.007, p
less than or equal to 0.001 respectively)(1,2,3,4) and patients
demonstrated improvement in role operation, including ability to do
everyday activities in work, home and in social situations.(5,6) In
addition, duloxetine significantly reduced the likeliness of get worse in
those patients wHO initially responded to duloxetine and were maintained on
treatment for six months compared with those switched to placebo.(7) The
most vulgar side personal effects in these studies included nausea, fatigue, dry
mouth, drowsiness, irregularity, insomnia, reduced appetite,
hyperidrosis (excessive perspiration), decreased libido, vomiting,
ejaculation delay and erectile disfunction.



Although global prevalence is not presently known, more than club
million Europeans(8,9) and six million the great unwashed in Central and South America
ar estimated to suffer from GAD(10), which is characterised by inordinate
anxiety and worry most a number of events and activities (such as
performance at work or school) over a free burning period of at least six
months.(11)



This regulatory favourable reception paves the way for launches in Europe and
applies to all 27 countries of the European Union, as well as Norway,
Iceland, and Liechtenstein.



Cymbalta(R), a member of a class of drugs commonly referred to as
serotonin and noradrenaline reuptake inhibitors,(12) is already approved by
the EMEA to process major depressive disorder and diabetic peripheral
neuropathic painful sensation. Duloxetine gained marketing authorisation for the
treatment of GAD in Mexico in 2006 and in the United States in 2007.

About Generalised Anxiety Disorder



Approximately nine billion Europeans(8,9) and six million people in
Central and South America are estimated to hurt from GAD.(10) Quality of
life is affected, as symptoms of GAD tin include overdone worry or
chronic anxiousness, irritability and poor concentration. Ability to work is
often compromised with the manifestation of physical symptoms such as
muscle tension, fatigue, sleep disturbance and nausea.(11) The sickness
tends to be continuing with periods of exacerbation and remitment. Patients
report that episodes of generalised anxiety disorder are often brought on,
or worsened, by nerve-racking life events.(13)

About Duloxetine



While duloxetine's mechanism of activity in world is not fully known, it
is believed to affect both serotonin- and
ntinence is marketed by Lilly under
the steel name Yentreve.(R)

References



(1) Koponen, H., et al. Efficacy of Duloxetine for the Treatment of
Generalized Anxiety Disorder: Implications for Primary Care Physicians.
Prim Care Companion J Clin Psychiatry 2007: 9(2):100-107



(2) Rynn M., et al. Efficacy and Safety of Duloxetine in the Treatment of
Generalized Anxiety Disorder: A Flexible-Dose, Progressive-Titration,
Placebo-Controlled Trial. Depression and Anxiety 2007: 25(3): 182-189.



(3) Hartford, J., et al. Duloxetine as an SNRI Treatment for Generalized
Anxiety Disorder: Results from a Placebo- and Active-Controlled Trial. Int
Clin Psychopharmacol 2007: 22(3):167-74.



(4) Nicolini H, et al. Improvement of psychic and somatic symptoms in
adult patients with generalized anxiety disorder: Examination from a
duloxetine, venlafaxine extended-release, and placebo-controlled study. In
Press at Psychological Medicine.



(5) Endicott, J., et al. Duloxetine Treatment for Role Functioning
Improvement in Generalized Anxiety Disorder: Three Independent Studies. The
Journal of Clinical Psychiatry 2007: 68(4):518-24



(6) Allgulander, C., et al. Pharmacotherapy of Generalized Anxiety
Disorder: Results of Duloxetine Treatment from a Pooled Analysis of 3
Clinical Trials. Current Medical Research and Opinion 2007: 23(6):
1245-1252



(7) Davidson JRT, et al. Duloxetine intervention for get worse prevention in
adults with generalized anxiety disorder: A 26-week randomised placebo-
controlled study. Poster presented at the American College of
Neuropsychopharmacology annual conference 2007. Boca Raton, Florida



(8) Lieb, R, et al. The epidemiology of generalized anxiety upset in
Europe. European Neuropsychopharmacology 2005 Aug;15(4):445-52.



(9) National Institute of Economic and Social Research. Summarized from
the National Institute Economic Review,194, 28 October 2005.



(10) Calculated extrapolations of prevalence rates against the
populations of a particular country or region, based upon prevalence of
generalized anxiety disorder in the US, UK, Canada or Australia. Available
at:
hTTP://www.cureresearch.

Download Omni Trio mp3

Artist: Omni Trio: mp3 download    Genre(s):  Drum & Bass Jungle     Discography:      Thru The Vibe Remixes    Year: 2003    Tracks: 2      Omni Trio    Year: 2003    Tracks: 2      Even Angels Cast Shadows    Year: 2001    Tracks: 5      Old Scool D'n'B    Year: 2000    Tracks: 7      Soul Promenade (Promo)    Year: 1994    Tracks: 2 Actually the single force of unmatched Rob Haigh, Omni Trio's gay steel of intricate, orchestrated drum'n'bass has been ontogenesis in herald since the approach of "ambient" or "intelligent" jungle in the mid-'90s brought identify calling such as L.T.J Bukem, Spring Heel Jack, and TPower to the stem. Into his 30s, Haigh already had a tenner on to the highest degree of those name calling, a fact communicated in the frequently more eclectic influence behindhand his tunes -- from Carl Craig and Mantronix to Miles Davis and Can. An acolyte of London's mid-'80s experimental industrial/avant-garde scene, Haigh's first Omni Trio releases -- a series of 12-inches issued in classifiable, color-coded sleeves -- started to look in the early '90s. Following on the heels of former hard-core and darkside techno, Haigh's tunes were among the first base composed remote of jungle's immediate dancefloor loop, and were other examples of the music's voltage to draw on a all-embracing range of sources (ambient, sign of the zodiac, jazz, soul) for influence. His number one full-length album, Volume 1: The Deepest Cut, was released on Moving Shadow in 1995 and combined many of those early 12-inch tracks -- "Mystic Stepper," "Apostate Snares" -- with some stunning production and remix work on by Foul Play (on "Snares"), among others. His proper debut, Obsessed Science, was released by Moving Shadow in 1996; Skeleton in the closet Keys followed in 1997. In addition to his progressively successful career as a recording creative person and remixer, Haigh also owns and operates a record shop in Hertford.

Role Of Obesity In Preeclampsia Studied At University Of Pittsburgh

Soak

   
Artist: Soak

   Genre(s): 
Trance
   Other
   

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Discography:


   
 Miraflores

   Year: 2007   
Tracks: 4


   
 Soak

   Year: 1997   
Tracks: 13

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Androgene

   
Artist: Androgene

   Genre(s): 
Other
   

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Discography:


   
 The Album

   Year: 2004   
Tracks: 9

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Led Zeppelin DVD Of O2 Arena Show Coming?

Led Zeppelin could release a DVD of their reunion show at London's O2 Arena, that took place in December last year.

Two members of the band - guitarist Jimmy Page and bassist John Paul Jones - have not ruled out the DVD. When asked by BBC 6Music if fans can expect the release, Page said: "I hope so one day, yeah."

Although Jones did admit that "there is no hurry" to release the DVD, before adding: "It was a special occasion you know and we really wanted that just to be it really."

See Also

• Shelley slams Genesis, Police reunions
• Sodom
• Bud Bundy: I’ll Sign Anything … But That!
• Madonna Denies Hiring Divorce Lawyer

Candie Payne

   
Artist: Candie Payne

   Genre(s): 
Indie
   

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Discography:


   
 I Wish I Could Have Loved You More

   Year: 2007   
Tracks: 11

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A singer/songwriter with a bent toward '60s influenced pop with indie Candie Payne was natural in Liverpool in 1983. However, she fatigued very much of her youth in Jackson Heights, Queens, NY, where she moved with her parents until reversive to England at eld ten. The sis of musician brothers Howie Payne – erstwhile of the Stands -- and drummer Sean Payne of the Zutons, Payne first-class honours degree played out time perusing art in college ahead falling out to pursue music. Influenced early on by such iconic jazz vocalists as Billie Holiday and Ella Fitzgerald, Payne likewise listened to heavily to a wide change of pop and rock music that she in the end brought to assume on her have songs. After working with several local Liverpool bands, Payne was introduced to producer Simon Dine and the pair began writing together. Evincing a '60s girl mathematical group and Motown-influenced vibe, Payne's debut album, I Wish I Could Have Loved You More, featured the Mark Ronson-produced single "Unitary More Chance" and was released on Sony in 2007.





Tomas Walker

J-Kwon

   
Artist: J-Kwon

   Genre(s): 
Other
   

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Discography:


   
 Hood Hop

   Year: 2006   
Tracks: 18


   
 Tipsy

   Year: 2004   
Tracks: 4

---

J-Kwon's path to celebrity included mooning Arista drumhead L.A. Reid and mocking producer Jermaine Dupri. These events helped realise the MC a narrow with the latter's So So Def, a subsidiary company of the former's employer. However, his animation was far more than roiled earlier that; kicked stunned his mother's mansion at the eld of 12, he took to the street, dealt break cocain, and had his chat broken after defeating a fellow MC in struggle. His label deal helped bend that about. Before turning 18, his debut single, "Tipsy," had reached the Top Ten of precisely about every singles chart. Overseen by Dupri and produced near in full by the Track Boyz, J-Kwon's full-length debut -- Hoodlum Hop, released in March of 2004 -- appeared precisely as the hit was decent unavoidable.

Angelina Jolie makes surprise visit to Baghdad

UN goodwill ambassador and Hollywood star Angelina Jolie has travelled to Iraq on a humanitarian mission and met with officials to demand help for people displaced by the war.
Although a scheduled press conference at the US embassy was cancelled, the Oscar-winning actress spoke to CNN telling the station that she wanted more to be done for the Iraqi families driven from their homes.
The 32-year-old said: "There are over two million displaced people and there never seems to be a real coherent plan to help them. There's lots of good will and lots of discussion but there seems to be a lot of talk at the moment and a lot of pieces that need to be put together."
The US embassy in Baghdad confirmed that Jolie had lunch with US troops serving in Iraq and had held a meeting with their top commander General David Petraeus, senior diplomats and Iraq's minister for displaced people.
A US embassy official told AFP: "She is here in her official capacity as a UN goodwill ambassador to meet with US, Iraqi and NGO officials to discuss internally displaced persons."
She also held talks in Baghdad's fortified Green Zone with the UN head of mission Staffan di Mistura and there were also plans for her to meet Iraq's Prime Minister Nuri al-Maliki, a US official said.
Jolie told CNN: "Of the two million internally displaced, it's estimated 58% are under 12-years-old. It's a very high number of people in a very, very vulnerable situation and a lot of young kids".
"So far, the different US officials I met with and different local people I've met with all have shared concerns, very, very strongly. They have spoken out about the humanitarian crisis, but there seems to be a block in," said the star.
Jolie continued: "What happens in Iraq and how Iraq settles in the years to come is going to affect the entire Middle East. And a big part of what it's going to affect, how it settles, is how these people are returned and settled into their homes and their community and brought back together and whether they can live together and what their communities look like."
She added: "It's in our best interest to address a humanitarian crisis on this scale because displacement can lead to a lot of instability and aggression."
Jolie is no stranger to the country. In August 2007, she met some of the 1,200 Iraqis stranded on the border between Iraq and Syria and appealed for more international support for those affected by the Iraq conflict.
During that tour, Jolie left UNHCR officials to visit privately with US and other multinational forces based in the area.
The following month, she launched a $150m appeal by UNICEF, the UN's fund for children, and the UN High Commissioner for Refugees to help educate 1m children affected by the war.

LiveDailiy Weekend, April 11: Stone Temple Pilots, Prince, U2 and more

LiveDailiy Weekend, April 11: Stone Temple Pilots, Prince, U2 and more

This week's

Fiasco's Ill Health Is The Result Of Hard Work

Fiasco's Ill Health Is The Result Of Hard Work

Rapper LUPE Fiasco has blamed the stresses of the euphony manufacture for damaging his health.
The Genius hitmaker, real name Wasalu Elijah Muhammad Jaco, reveals he has been hospitalised several times for an undisclosed malady over the close few months, because he has been workings so hard to cut up out a successful life history in the hip-hop manufacture.
His wellness problems still prevented him from attention the Grammy Awards earlier this year (Feb08), where he was nominated for foursome prizes.
He tells MTV.com, "When I got to the pivotal moment where you get the accolades for it (music), I establish myself in the hospital and the dr. telling me I can't even go.
"I had a long conversation with the doctor, and he doesn't cognise me from Adam. He just came in and said, 'This is your sprightliness. This is how hard you're sledding. What happens when there's zilch there, and you drop down once again?'"
And the lyrist insists there is little to keep him from fulfilling his previous promise to quit music after his next album.
He adds, "I don't desire to allege I'm 100 per cent certainly (of quitting), like, 'Yeah, this is it.' Merely 85 per cent.
"That 15 percent is the X gene. That could be bills. Like, 'Lupe, you got to pay the bills.' 'Oh, man, I got to put out another album'."














Dorival Caymmi

Longoria's husband sues celeb site

Longoria's husband sues celeb site

The married man of 'Desperate Housewives' adept Eva Longoria, Tony Parker, is suing a celebrity causerie website for at least $40m over allegations that he had an thing with a French model.
The Associated Press reports that basketball game star Charles Christopher Parker alleges the internet site X17online posted "treasonably and defamatory" messages around him.
The lawsuit said: "This is false. It ne'er happened. And X17 had to recognize that the story was faithlessly, or, at the very least, it had to get entertained serious doubts around the credibility of its supposed author."
The suit also said that the web site never contacted the couple or their representatives in front publication the allegations, and refused to retract them subsequently being told the allegations were false.

Noel Gallagher voted coolest man

Noel Gallagher voted coolest man

Haven asterisk Christmastide Gallagher is the coolest man in U.K., according to a survey of young workforce.
The singer may birth celebrated his 40th birthday this year, only he was voted way ahead of offspring pretenders such as North Frigid Zone Rapscallion Alex Turner.
Liverpool and England football player Steven Gerrard was indorsement in the C Coolest Brits Workforce of 2007 list compiled by Zoo magazine publisher.
'Doctor Who's Saint David Tennant was third - deemed to be tank than current James IV Bond Daniel Craig, wHO was fourth.
David Beckham was fifth and Formula I star Lewis Hamilton sixth.
Comedians Simon the Canaanite Pegg and Ricky Gervais were ranked seventh and one-eighth severally, followed by boxer and BBC Sports Personality of the Twelvemonth Joe Calzaghe.
North Frigid Zone Monkeys frontman Turner brought up the back in 10th place.The Round top 20 included boxer Ricky Hatton, Chelsea defender John Lackland Terry cloth and 'Top Gear' donor Jeremy Clarkson.
Patch Christmastide Gallagher headed the name, his younger brother Liam scraped in at number 22.
Zoological garden editor Ben Sweeney Todd said: "These inauguration awards ingest revealed roughly quite an surprising results with Yuletide Gallagher, world Health Organization has acquired something of an 'elder statesman' function, topping the poll.
"It shows that he is individual young people today strive to be like - perchance even to a greater extent so than when Oasis dominated the charts a tenner ago."
The list contained a handful of older stars, including Saint Paul Sir James Paul McCartney at 55 and Mickey Michael Philip Jagger at 73.
Paul Simon Cowell was a late entrant at number 98.

The Ice Man Restraineth

The Ice Man Restraineth

Vanilla Sparkler is departure from the cooler to the hot seat.The former hit-making hip-hopster was released from Palm tree Beach County Gaol pursuit a court appearance Fri morning, hours after acquiring arrested for shoving his married woman.Malefactor Court Justice Nancy Perez placed Ice, aka Henry M. Robert Caravan Wink, on supervised release without bond certificate and ordered him to continue away from Mrs.. Ice, aka Laura Van Winkle out, until the court of justice can buoy form a final decision in the case."I love my married woman and I know she feels bad about this," Van Winkle told Perez."Good portion to you," said Perez.Outside the clink, Ice's agent, Wes Kain, labeled the incident "a misunderstanding."According to Teri Barbera, spokeswoman for the Palm Beach County Sheriff's Office, the rapper faces i weigh of simple house servant battery and will now enter the Palm Beach County Supervised Have Recognizance broadcast, which requires him to be apart from his missis and have no physical touch with her.He buttocks, however, middleman her by sound, and the adjudicate granted him tribulation with their two children, 8-year-old Dustee Rainwater and 10-year-old Keelee Gentle wind, as long as he's in the presence of his neighbour, Frank Morales.The 40-year-old Frappe was besides allowed to pay up a onetime inflict to the couple's Hessian boot home escorted by a police officer to gather up his personal personal effects. Differently, he must stay forth until the domestic battery charge is resolved.Per the turn back report card, the one-hit admiration was taken into custody and booked at or so 10:43 ET Monday, after his mate called 911 and reported she had been hit and kicked by Internal-combustion engine later on getting into a fighting over the purchase of a chamber jell. Laura Van Scintillate said the incident occurred in front of unity of their children.Officers turned up at about 7:15 p.m. and tracked land Internal-combustion engine, world Health Organization was on his motorcycle about two blocks away from the house. By the time law got back to the house, Laura Vanguard Winkle altered her story, claiming she had only been pushed, she wasn't in fear for her safety, and she wanted a split up. She and then refused to say anything more until she wheel spoke to her attorney.ICE denied pushing her and insisted that he hopped on his bike to scram away from her, non the cops. He as well said they had been disputation for two years, per the law report, and that his wife was bipolar and sometimes "irrational number."An arraignment in the case is tentatively scheduled for May 5, Barbera said.The "Ice Water ice Baby" rapper and former Surreal Life history star is no unknown to house servant disturbances.In 2001, he was arrested well-nigh Davie, Everglade State, for supposedly grabbing his wife's hair during a heated argument in the couple's gondola, just Laura declined to join forces with police and the casing was dropped.In recent epoch years he has gotten in trouble for a serial of motoring miscues and was fined afterwards his darling wallaroo and goat escaped and wandered around town. 

Two films top the Oscars shortlist

Two films top the Oscars shortlist

The nominations for the 80th Academy Awards have been announced, with 'No Country for Old Men' and 'There Will Be Blood' leading the short list with octad nominations each.
'Atonement', 'Juno' and 'Michael Clayton' have also received numerous nominations.
As expected Wicklow house physician Daniel Day-Lewis has been nominated for a Best Thespian Oscar for his performance in 'There Volition Be Blood'.
The other nominees for C. H. Best Actor are: George V Clooney ('Michael Clayton'), Rebel Depp ('Sweeney Todd'), Tommy Lee Jones ('In the Valley of Elah') and Viggo Mortensen ('Eastern Promises').
The Best Actress shortlist is: Cate Blanchett ('Elizabeth: The Golden Age'), Julie Christie ('Away from Her'), Marion Cotillard ('La Compete en Rose'), Laura Linney ('The Savages') and Ellen Page ('Juno').
The nominees for Best Supporting Worker ar: Casey Affleck ('The Blackwash of Jesse James River by the Sir Noel Pierce Coward Henry M. Robert Ford'), Javier Bardem ('No Nation for Old Men'), Duke of Edinburgh Jane Seymour Malvina Hoffman ('Charlie Wilson's War'), Hal Holbrook ('Into the Wild') and Tom Sir Geoffrey Wilkinson ('Michael Clayton').
Along with Irish people teen Saoirse Ronan, Cate Blanchett ('I'm Non There'), Ruby Dee ('American Gangster'), Amy Ryan ('Gone Baby Gone') and Tilda Swinton ('Michael Clayton') make been nominated in the Best Support Actress category.
Shortlisted for Best Director ar: Julian Schnabel ('The Diving Vanessa Stephen and the Butterfly'), Jason Reitman ('Juno'), Tony Gilroy ('Michael Clayton'), Joel and Ethan Coen ('No Country for Old Men') and Paul the Apostle St. Thomas Carl David Anderson ('There Will Be Blood').
The films nominated for Best Ikon are: 'Atonement', 'Michael Clayton', 'No Country for Old Men', 'There Volition Be Blood' and 'Juno'.
The five films nominated for Best Foreign Cinema are: 'The Counterfeiters' (Oesterreich), 'Beaufort' (Yisrael), 'Katyn' (Republic of Poland), 'Mongol' (Kazakh) and '12' (Russia).
The nominees for C. H. Best Infotainment Feature ar: 'No End in Sight', 'Operation Homecoming: Composition the Wartime Experience', 'Sicko', 'Taxi to the Darkness Side' and 'War/Dance'. 
The nominees for Best Animated Film are: 'Persepolis', 'Ratatouille' and 'Surf's Up'.
The nominees for Best Adapted Screenplay are: Saint Christopher Hampton ('Atonement'), Sarah Polley ('Away from Her'), Ronald Harwood ('The Dive Bell and the Butterfly'), Joel and Ethan Coen ('No Country for Old Men') and Paul Norman Mattoon Thomas Anderson ('There Will Be Blood').
The nominees for Best Original Screenplay are: Diablo William Frederick Cody ('Juno'), Nancy Oliver ('Lars and the Real Girl'), Tony Gilroy ('Michael Clayton'), January Pinkava, Jim Capobianco and Brad Shuttle ('Ratatouille') and Tamara Jenkins ('The Savages').
For more on the Oscar nominations, click here and here.




Argent

Feast For The Crows

   
Artist: Feast For The Crows

   Genre(s): 
Metal: Alternative
   

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Discography:


   
 When All Seems To Be Burned

   Year: 2007   
Tracks: 9

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